Ethanolamine plasmalogen metabolism in myelinating rat brain
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چکیده
منابع مشابه
Synthesis of phosphatidylethanolamine and ethanolamine plasmalogen by the CDP-ethanolamine and decarboxylase pathways in rat heart, kidney and liver.
Studies with mammalian cell lines have led to suggestions that mammalian tissues may derive all of their phosphatidylethanolamine (PE) from the decarboxylation of phosphatidylserine (PS), and also that the physiological significance of the CDP-ethanolamine pathway was the synthesis of ethanolamine plasmalogen. We have therefore investigated the biosynthesis of PE and ethanolamine plasmalogen vi...
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Plasmalogens are a major sub-class of ethanolamine and choline phospholipids in which the sn-1 position has a long chain fatty alcohol attached through a vinyl ether bond. These phospholipids are proposed to play a role in membrane fusion-mediated events. In this study, we investigated the role of the ethanolamine plasmalogen plasmenylethanolamine (PlsEtn) in intracellular cholesterol transport...
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The effects of neonatal thyroid status on the metabolism of the myelin metabolite, galactosyl diacylglycerol, were examined in developing rat brain. There was a 40% reduction in the concentration of monogalactosyl diacylglycerol in the brains of 20and 23-day-old rats which were made hypothyroid at birth. These same animals had a retarded developmental pattern for the galactosyltransferase activ...
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1,2-Hep tadecanediol-2-14C was administered intracerebrally to 18-day-old rats, and its incorporation, after 8 hr, into the individual aliphatic moieties of the ethanolamine glycerophosphatides was determined. Much of the radioactivity was found in a lipid fraction identified as 1 -0-2‘-hydroxyheptadecyl glycerol. Evidence is presented that a major portion of the precursor was incorporated into...
متن کاملLong-chain cyclic acetals of glycerol: metabolism of the stereomeric 1,3-dioxanes and 1,3-dioxolanes in myelinating rat brain.
The metabolism of the stereomeric cyclic glycerol acetals of [1-(14)C]hexadecanal was studied in myelinating rat brain. It was found that the four isomers, cis- and trans-2-pentadecyl-5-hydroxy-1,3-dioxanes and cis- and trans-2-pentadecyl-4-hydroxymethyl-1,3-dioxolanes, were utilized by the tissue at different rates. The acetals were primarily metabolized via a ring-opening mechanism leading to...
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ژورنال
عنوان ژورنال: Biochemical Journal
سال: 1970
ISSN: 0306-3283
DOI: 10.1042/bj1190043pb